🔬 Eldric Science Worker

AI-powered scientific computation engine with 140+ APIs spanning space agencies, particle physics, gravitational waves, quantum computing, bioinformatics, CRISPR design, drug discovery, neuroscience, and laboratory management with multi-backend LLM integration for intelligent research assistance.

eldric-scienced v4.1.0 · Port 8897 🤖 AI-Assisted Research

🚀 New: AI-Assisted Research

The Science Worker now integrates with any LLM backend (Ollama, vLLM, OpenAI, Anthropic) for AI-assisted analysis. Generate hypotheses, interpret results, design experiments, and delegate complex research tasks to the Agent Worker's multi-agent system.

What Can You Do?

🧬

Analyze Sequences

Upload DNA, RNA, or protein sequences for comprehensive analysis including GC content, molecular weight, translation, and BLAST search.

✂️

Design CRISPR Guides

Generate optimized guide RNAs for Cas9/Cas12a with off-target prediction, efficiency scoring, and base/prime editing support.

💊

Discover Drugs

Perform molecular docking, predict ADMET properties, and analyze drug-target interactions with GPU acceleration.

🏢

Manage Lab Data

Track samples, experiments, and protocols with full regulatory compliance (FDA 21 CFR Part 11, GLP, GMP).

🤖

AI Analysis

Use LLMs to interpret results, generate hypotheses, suggest experiments, and write research summaries automatically.

⚡

xLSTM Anomaly Detection

Detect anomalies in scientific datasets using Sepp Hochreiter's xLSTM architecture. Real-time monitoring of experimental data streams, sensor readings, and time-series measurements.

🔗

Access 140+ APIs

Query NASA, CERN, LIGO, JWST, NCBI, UniProt, and 140+ scientific APIs across 19 domains through a unified REST interface.

All Scientific Domains

🚀

Space Agencies

NASA (APOD, NEO, Mars Rover, Exoplanets, DONKI), ESA, Roscosmos, CNSA, JAXA, ISRO mission data and imagery.

🔭

Space Telescopes

Hubble archive, James Webb Space Telescope (JWST), Spitzer infrared, and Chandra X-ray observations.

⚛️

Particle Physics

CERN LHC datasets, DESY, Fermilab, HEPData repositories, INSPIRE-HEP literature, and PDG particle data.

🌊

Gravitational Waves

LIGO event catalog, GWOSC open science data, binary merger searches, and signal analysis.

🌌

Astronomy

ESO surveys, SDSS sky surveys, ALMA radio observations, and PanSTARRS transient detection.

🌍

Earth Sciences

USGS earthquakes and volcanoes, NOAA weather and solar data, seismic monitoring networks.

💻

Quantum Computing

IBM Quantum systems, quantum algorithms, error correction techniques, and circuit simulation.

🧱

Materials Science

Materials Project databases, Crystallography Open Database (COD), and NIST chemistry data.

🧬

Genomics

Ensembl genome browser, ENCODE regulatory data, GTEx expression, and HMDB metabolomics.

🧠

Neuroscience

Allen Brain Atlas, OpenNeuro datasets, and NeuroMorpho neuron morphology databases.

🌿

Climate & Environment

GBIF biodiversity, OBIS marine data, air quality indices, ice core records, and glacier monitoring.

🏥

Medical & Health

ClinicalTrials.gov, WHO data, GWAS catalog, OpenFDA, and PubMed literature search.

☢️

Nuclear & Fusion

IAEA nuclear databases, ITER fusion project status, and fusion research data.

🌾

Agriculture

FAOStat food and agriculture data, USDA plant databases, and nutritional information.

🏛️

Archaeology

Paleobiology Database (PaleoBio), Open Context archaeological data, and fossil records.

Architecture

Science Worker - AI-Integrated Research Platform
Data Worker Port 8892 • 140+ Scientific APIs • Databases • RAG Storage NASA, CERN LIGO, NCBI Science Worker Port 8897 · AI-Powered Computation 🧬 Bioinformatics BLAST, Align, Variants ✂️ CRISPR Guide Design, Off-target 💊 Drug Discovery Docking, ADMET 🏢 LIMS Samples, Compliance 🤖 AI-Assisted Research Analysis • Hypotheses • Experiments Multi-Backend: Ollama | vLLM | OpenAI | Anthropic Inference Worker Port 8890 • LLM Completion • Chat / Analysis • Embeddings Direct LLM Agent Worker Port 8893 • Multi-Agent Tasks • Literature Review • Protocol Generation • Agentic RAG Complex Tasks Controller :8880 Cluster • Licensing • Discovery LEGEND Data Flow AI Request

🔬 Research Agent

The Science Worker operates as an intelligent Research Agent that orchestrates federated searches across multiple scientific data providers. Rather than making direct API calls, it delegates to the Data Worker's 140+ scientific connectors and synthesizes results into comprehensive research reports with citations.

🌐 Federated Search Architecture

When you conduct research through the Science Worker, it automatically queries multiple providers simultaneously (arXiv, Crossref, OpenAlex, PubMed, Semantic Scholar, etc.), normalizes the heterogeneous responses, extracts citations, and synthesizes findings into a unified research report. The Data Worker handles rate limiting, caching, and API authentication for all 140+ providers.

Federated Research Pipeline
Research Query "machine learning" topic: "ai" Science Worker Port 8897 executeFederatedSearch() synthesizeResearch() delegate Data Worker Port 8892 arXiv Crossref OpenAlex PubMed S2 + 135 more Query Templates Rate Limiting Research Report summary: "Found 10 sources..." citations: [{title, authors, date, DOI, snippet}...] key_findings: [...] sources_consulted: 5

Research Agent Endpoints

POST /api/v1/research/search

Federated search across multiple scientific providers

POST /api/v1/research/conduct

Full research workflow: search → synthesize → report

POST /api/v1/research/plan

Generate a research plan with suggested providers

GET /api/v1/research/providers

List available providers grouped by topic

Example: Conduct Research

curl -X POST http://localhost:8897/api/v1/research/conduct \ -H "Content-Type: application/json" \ -d '{ "query": "machine learning", "topic": "ai", "providers": ["arxiv", "crossref", "openalex", "pubmed", "semanticscholar"], "max_results_per_provider": 5 }' # Response: { "query": "machine learning", "summary": "Found 10 sources across 4 providers. AI synthesis unavailable...", "citations": [ { "title": "Scikit-learn: Machine Learning in Python", "authors": "Pedregosa et al.", "date": "2011", "id": "10.5555/1953048.2078195", "provider": "crossref", "snippet": "Scikit-learn is a Python module integrating..." }, ... ], "key_findings": ["Machine learning with sklearn (crossref)", ...], "sources_consulted": 5, "sources_cited": 10, "generated_at": "2026-02-01T15:13:56Z" }

Supported Research Topics

📚 Literature

arXiv, Crossref, OpenAlex, PubMed, Semantic Scholar, Europe PMC

🧬 Life Sciences

NCBI, UniProt, Ensembl, PDB, ChEMBL, MyGene, ClinicalTrials

🌍 Earth Sciences

NOAA, USGS, Copernicus, GBIF, OBIS, iNaturalist, eBird, Ice Cores, Glaciers

⚛️ Physics & Particle

CERN LHC, DESY, Fermilab, HEPData, INSPIRE-HEP, PDG, LIGO, GWOSC

🚀 Space & Astronomy

NASA, ESA, JAXA, ISRO, Hubble, JWST, Spitzer, Chandra, ESO, SDSS, ALMA, PanSTARRS

🔬 Chemistry & Materials

PubChem, COD, Materials Project, NIST Chemistry

💊 Pharma & Medical

OpenFDA, DrugBank, ChEMBL, ClinicalTrials, WHO, GWAS, PubMed

🧠 Neuroscience

Allen Brain Atlas, OpenNeuro, NeuroMorpho

💻 Quantum & Nuclear

IBM Quantum, IAEA, ITER, Fusion Research

🌾 Agriculture & Archaeology

FAOStat, USDA Plants, Food Databases, PaleoBio, Open Context

🤖 AI-Assisted Research

The Science Worker integrates with multiple LLM backends to provide intelligent research assistance. Use AI for basic tasks directly, or delegate complex multi-step research to the Agent Worker.

AI Research Workflow
📊 DATA BLAST Results Docking Scores 🤖 ANALYZE Summarize Interpret 💡 HYPOTHESIZE Generate Ideas Rank Confidence 🧪 DESIGN Suggest Experiments Generate Protocols 📝 REPORT Literature Review Multi-Agent Analysis
💬

Direct LLM Access

For quick AI tasks, query LLMs directly through any configured inference backend.

  • Text completion for research summaries
  • Multi-turn chat for interactive analysis
  • Data interpretation and summarization
  • Hypothesis generation with confidence scores
  • CRISPR guide evaluation with AI scoring
  • Drug target prediction assistance
  • Experiment suggestion with protocols
Supported Backends
Ollama
vLLM
OpenAI
Anthropic
TGI
llama.cpp
🔗

Agent Worker Delegation

For complex multi-step tasks, delegate to the Agent Worker's multi-agent system.

  • Complex research task delegation
  • Automated literature reviews (up to 20+ papers)
  • Multi-agent collaboration (Researcher + Validator)
  • Protocol generation with constraints
  • Agentic RAG with iterative retrieval
  • Query decomposition for complex questions
  • Knowledge base integration
Agent Types
Researcher
Validator
Planner
Coder

AI API Endpoints

GET /api/v1/ai/status

Check LLM and Agent Worker availability

POST /api/v1/ai/completion

Generate text completion for research tasks

POST /api/v1/ai/chat

Multi-turn chat for interactive research

POST /api/v1/ai/analyze

AI analysis: summarize, interpret, suggest, compare

POST /api/v1/ai/hypothesis

Generate research hypotheses with confidence scores

POST /api/v1/ai/experiments

Get experiment suggestions with protocols

POST /api/v1/agent/research

Delegate complex research to Agent Worker

POST /api/v1/agent/literature

Request automated literature review

POST /api/v1/agent/multi-analysis

Multi-agent collaborative analysis

POST /api/v1/agent/protocol

Generate experimental protocols

Computational Features

🧬

Bioinformatics Engine

DNA/RNA/protein sequence analysis with built-in algorithms for molecular biology research.

  • Sequence analysis (GC content, molecular weight, melting temp)
  • DNA translation (6-frame, codon optimization)
  • BLAST alignment (local database or NCBI)
  • Multiple sequence alignment (Clustal, MUSCLE)
  • Variant calling and annotation (VCF)
  • Phylogenetic tree construction
Integrated Tools

BLAST+, HMMER, Clustal Omega, MUSCLE, SAMtools, BCFtools

✂️

CRISPR Design

Guide RNA design with off-target analysis and efficiency prediction for genome editing.

  • Cas9/Cas12a guide RNA design
  • Off-target site prediction (CFD/MIT scoring)
  • On-target efficiency prediction (Rule Set 2)
  • Base editing guide design (ABE/CBE)
  • Prime editing (pegRNA design)
  • HDR template generation
Algorithms

Doench scoring, CFD scoring, Lindel prediction, DeepCRISPR

💊

Drug Discovery

Molecular docking, property prediction, and structure analysis for pharmaceutical research.

  • Molecular docking (AutoDock Vina, GNINA)
  • ADMET property prediction
  • Lipinski Rule of Five / Veber rules
  • SMILES/InChI parsing and validation
  • Molecular fingerprints (ECFP, MACCS)
  • AlphaFold structure prediction integration
Integrated Tools GPU

AutoDock Vina, GNINA, RDKit, Open Babel, ESMFold

🏢

LIMS (Laboratory Management)

Laboratory Information Management with regulatory compliance for research environments.

  • Sample registration and barcode tracking
  • Experiment workflow management
  • Equipment calibration tracking
  • Reagent inventory management
  • Audit trails (21 CFR Part 11 compliant)
  • GLP/GMP compliance modes
Compliance

FDA 21 CFR Part 11, EU Annex 11, ISO 17025, GLP, GMP

API Coverage: 140+ Scientific Endpoints

The Science Worker provides a unified REST API gateway to 140+ scientific endpoints across 19 domains. All endpoints are accessible at http://scienceworker:8897.

Category Endpoints
Space Agencies /api/v1/nasa/*, /api/v1/esa/*, /api/v1/roscosmos/*, /api/v1/cnsa/*, /api/v1/jaxa/*, /api/v1/isro/*
Space Telescopes /api/v1/hubble/*, /api/v1/jwst/*, /api/v1/spitzer/*, /api/v1/chandra/*
Particle Physics /api/v1/cern/*, /api/v1/desy/*, /api/v1/fermilab/*, /api/v1/hepdata/*, /api/v1/inspire/*, /api/v1/pdg/*
Gravitational Waves /api/v1/ligo/*, /api/v1/gwosc/*
Astronomy /api/v1/eso/*, /api/v1/sdss/*, /api/v1/alma/*, /api/v1/panstarrs/*
Earth Sciences /api/v1/earthquakes, /api/v1/volcanoes/*, /api/v1/noaa/*, /api/v1/seismic/*
Quantum Computing /api/v1/quantum/*, /api/v1/arxiv/quantum
Materials Science /api/v1/materials/*, /api/v1/cod/*, /api/v1/nist/*
Genomics /api/v1/ensembl/*, /api/v1/encode/*, /api/v1/gtex/*, /api/v1/hmdb/*
Neuroscience /api/v1/allen-brain/*, /api/v1/openneuro/*, /api/v1/neuromorpho/*
Climate & Environment /api/v1/gbif/*, /api/v1/obis/*, /api/v1/air-quality, /api/v1/ice-cores, /api/v1/glaciers/*
Medical & Health /api/v1/clinical-trials, /api/v1/who/*, /api/v1/gwas/*, /api/v1/openfda/*, /api/v1/pubmed/*
Nuclear & Fusion /api/v1/iaea/*, /api/v1/iter/*, /api/v1/fusion/*
Agriculture /api/v1/faostat/*, /api/v1/usda-plants, /api/v1/food/*
Archaeology /api/v1/paleobio/*, /api/v1/archaeology/*, /api/v1/open-context
Bioinformatics /api/v1/bio/analyze, /api/v1/bio/translate, /api/v1/bio/align, /api/v1/bio/blast, /api/v1/bio/variants
Pharmaceutical /api/v1/pharma/compound, /api/v1/pharma/dock, /api/v1/pharma/admet, /api/v1/pharma/structure
CRISPR /api/v1/crispr/design, /api/v1/crispr/offtargets, /api/v1/crispr/base-edit, /api/v1/crispr/prime-edit
LIMS /api/v1/lims/samples, /api/v1/lims/experiments, /api/v1/lims/audit/*

REST API

Space & Astronomy

GET /api/v1/nasa/apod

NASA Astronomy Picture of the Day

POST /api/v1/nasa/neo

Near Earth Object tracking and data

POST /api/v1/nasa/mars

Mars Rover photos and mission data

POST /api/v1/nasa/exoplanets

Exoplanet archive queries

POST /api/v1/jwst/*

James Webb Space Telescope observations

POST /api/v1/hubble/*

Hubble Space Telescope archive

Particle Physics & Gravitational Waves

POST /api/v1/cern/search

Search CERN LHC datasets by experiment

POST /api/v1/ligo/search

Search gravitational wave events

GET /api/v1/gwosc/*

Gravitational wave open science catalog

POST /api/v1/inspire/*

INSPIRE-HEP literature search

Earth Sciences & Climate

POST /api/v1/earthquakes

USGS earthquake data by magnitude and region

GET /api/v1/volcanoes/*

Active volcano monitoring data

POST /api/v1/noaa/*

NOAA weather and solar activity data

GET /api/v1/ice-cores

Ice core climate records

GET /api/v1/glaciers/*

Glacier monitoring and retreat data

GET /api/v1/air-quality

Global air quality indices

Quantum, Nuclear & Neuroscience

POST /api/v1/quantum/*

Quantum computing systems and algorithms

GET /api/v1/iaea/*

IAEA nuclear databases

GET /api/v1/iter/*

ITER fusion project status

POST /api/v1/allen-brain/*

Allen Brain Atlas neural data

POST /api/v1/openneuro/*

OpenNeuro neuroimaging datasets

POST /api/v1/neuromorpho/*

Neuron morphology database

Medical, Agriculture & Archaeology

POST /api/v1/clinical-trials

ClinicalTrials.gov search by condition/status

GET /api/v1/who/*

WHO health statistics and disease data

POST /api/v1/openfda/*

FDA drug events and recalls

GET /api/v1/faostat/*

FAO food and agriculture statistics

GET /api/v1/usda-plants

USDA plant database

POST /api/v1/paleobio/*

Paleobiology Database fossil records

Bioinformatics

POST /api/v1/bio/analyze

Analyze DNA/RNA/protein sequence (GC%, MW, Tm)

POST /api/v1/bio/translate

Translate DNA to protein (all reading frames)

POST /api/v1/bio/blast

BLAST search against local or NCBI databases

POST /api/v1/bio/align

Multiple sequence alignment

POST /api/v1/bio/variants

Variant calling from alignment

CRISPR

POST /api/v1/crispr/design

Design guide RNAs for target sequence

POST /api/v1/crispr/offtargets

Predict off-target sites for guide

POST /api/v1/crispr/base-edit

Design base editing guides (ABE/CBE)

POST /api/v1/crispr/prime-edit

Design prime editing guides (pegRNA)

Drug Discovery

POST /api/v1/pharma/compound

Parse SMILES, calculate molecular properties

POST /api/v1/pharma/dock

Molecular docking (Vina/GNINA)

POST /api/v1/pharma/admet

ADMET property prediction

POST /api/v1/pharma/structure

Fetch/predict protein structure

LIMS

POST /api/v1/lims/samples

Register new sample

GET /api/v1/lims/samples/{id}

Get sample by ID or barcode

POST /api/v1/lims/experiments

Create experiment record

GET /api/v1/lims/audit/{type}/{id}

Get audit trail (compliance)

Quick Start

# Install Science Worker sudo dnf install eldric-scienced-4.1.0-1.el9.x86_64.rpm # Start daemon with AI support sudo systemctl start eldric-scienced # Or run manually with all integrations eldric-scienced --port 8897 \ --controller http://controller:8880 \ --inference-workers http://localhost:8890 \ --agent-workers http://localhost:8893 \ --data-workers http://localhost:8892 \ --gpu --cuda-devices 0,1

Example: AI Analysis of BLAST Results

# First, run a BLAST search curl -X POST http://localhost:8897/api/v1/bio/blast \ -H "Content-Type: application/json" \ -d '{"sequence": "ATGCGATCG...", "database": "nr"}' # Then analyze results with AI curl -X POST http://localhost:8897/api/v1/ai/analyze \ -H "Content-Type: application/json" \ -d '{ "data": { "blast_results": [...] }, "type": "interpret" }' # Response: { "analysis_type": "interpret", "analysis": "The BLAST results show significant homology to...", "model": "llama3.1:70b" }

Example: Generate Research Hypothesis

curl -X POST http://localhost:8897/api/v1/ai/hypothesis \ -H "Content-Type: application/json" \ -d '{ "context": "We observed increased expression of BRCA1 in tumor samples compared to normal tissue. The expression correlated with patient age but not tumor stage..." }' # Response includes ranked hypotheses with confidence scores

Example: Automated Literature Review

curl -X POST http://localhost:8897/api/v1/agent/literature \ -H "Content-Type: application/json" \ -d '{ "topic": "CRISPR-Cas9 off-target effects in therapeutic applications", "max_papers": 20 }' # Agent Worker searches PubMed, arXiv, bioRxiv and generates a comprehensive review

Configuration

{ "port": 8897, "controller_url": "http://controller:8880", "data_worker_urls": ["http://localhost:8892"], "inference_worker_urls": ["http://localhost:8890"], "agent_worker_urls": ["http://localhost:8893"], "llm": { "default_model": "llama3.2:3b", "research_model": "llama3.1:70b", "max_tokens": 4096, "temperature": 0.7, "enable_streaming": false, "timeout_ms": 120000 }, "bioinformatics_backend": "default", "blast_databases_path": "/data/blast_db", "pharma_backend": "default", "pdb_cache_path": "/data/pdb_cache", "lims_database_path": "/data/lims.db", "compliance_mode": "fda_21_cfr_11" }

License Tiers

Feature Free Standard Professional Enterprise
Sequence Analysis ✓ ✓ ✓ ✓
AI Analysis Basic ✓ ✓ ✓
Agent Delegation ✗ ✓ ✓ ✓
CRISPR Design 5/day 50/day 500/day Unlimited
BLAST Search ✗ ✓ ✓ ✓
Molecular Docking ✗ ✗ ✓ ✓
AlphaFold Integration ✗ ✗ ✗ ✓
LIMS Samples 10 100 1,000 Unlimited
21 CFR Part 11 ✗ ✗ ✗ ✓
GPU Acceleration ✗ ✓ ✓ ✓
Science Workers 1 2 5 Unlimited

Port Reference

Component Port Description
Science Worker 8897 Scientific computation + AI research
Controller 8880 Cluster management, licensing
Data Worker 8892 Databases, scientific APIs (140+), RAG storage
Inference Worker 8890 LLM inference (Ollama, vLLM, OpenAI...)
Agent Worker 8893 Multi-agent tasks, agentic RAG

Related Documentation

🗄️

Data Worker

Access 140+ scientific APIs including NASA, CERN, LIGO, JWST, NCBI, UniProt, and more.
🤖

Agent Worker

Multi-agent system with agentic RAG for complex research tasks.
⚡

LLM Backends

Configure Ollama, vLLM, OpenAI, and other inference backends.